The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing

The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing

Background: Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue. Method: Bone healin...

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Bibliographic Details
Main Authors: Jessika Appelt, Anke Baranowsky, Denise Jahn, Timur Yorgan, Paul Köhli, Ellen Otto, Saeed Khomeijani Farahani, Frank Graef, Melanie Fuchs, Aarón Herrera, Michael Amling, Thorsten Schinke, Karl-Heinz Frosch, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:EBioMedicine
Subjects:
Fracture
Bone regeneration
Osteoblasts
Osteoclasts
Neuropeptides
αCGRP
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303467

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http://www.sciencedirect.com/science/article/pii/S2352396420303467

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