High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver

High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver

Abstract Precise molecular pathways involved in the progression of non-alcoholic steatohepatitis (NASH) remain to be elucidated. As Mallory–Denk bodies were occasionally observed in the enlarged hepatocytes in NASH model rat (SHRSP5/Dmcr) fed high-fat and high-cholesterol (HFC) diet, we aimed to cla...

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Bibliographic Details
Main Authors: Hisao Naito, Yuki Yoshikawa-Bando, Yuan Yuan, Sayuki Hashimoto, Kazuya Kitamori, Hiroshi Yatsuya, Tamie Nakajima
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-48973-w

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https://doi.org/10.1038/s41598-019-48973-w

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