Hydrocephalus in an Elderly Man with Systemic Lupus Erythematosus
A 71-year-old man presented with quadriplegia, seizures, dysarthria, motor aphasia and urinary incontinence lasting for several years. The development of proteinuria and increased susceptibility to infections brought the physician's attention to possible underlying autoimmune diseases. Laborato...
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doaj-f95d4b92faa54a2597b1203d317c423b2020-11-24T22:19:05ZengElsevierJournal of the Formosan Medical Association0929-66462009-06-01108651351710.1016/S0929-6646(09)60100-5Hydrocephalus in an Elderly Man with Systemic Lupus ErythematosusWei-Sheng Chen0Tsai-Hung Wu1Chung-Tei Chou2Chang-Youh Tsai3Division of Allergy, Immunology and Rheumatology, Taipei, TaiwanDivision of Nephrology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, TaiwanDivision of Allergy, Immunology and Rheumatology, Taipei, TaiwanDivision of Allergy, Immunology and Rheumatology, Taipei, TaiwanA 71-year-old man presented with quadriplegia, seizures, dysarthria, motor aphasia and urinary incontinence lasting for several years. The development of proteinuria and increased susceptibility to infections brought the physician's attention to possible underlying autoimmune diseases. Laboratory investigations revealed evidence for systemic lupus erythematosus (SLE) and antiphospholipid syndrome. Imaging studies showed obstructive hydrocephalus. Several courses of methylprednisolone therapies followed by maintenance therapy with low-dose steroid, ventriculoperitoneal shunt, and antihypertensives improved the proteinuria and dysarthria but not the urinary incontinence or dementia. A thromboembolic event in the central nervous system secondary to phospholipid antibodies or lupus activity may represent a pathogenetic basis for hydrocephalus. When encountering a patient with hydrocephalus but without apparent predisposing factors, it is always important to include SLE as a differential diagnosis.http://www.sciencedirect.com/science/article/pii/S0929664609601005antiphospholipid antibodieshydrocephalusneuropsychiatric systemic lupus erythematosus (NP-SLE)vasculitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei-Sheng Chen Tsai-Hung Wu Chung-Tei Chou Chang-Youh Tsai |
spellingShingle |
Wei-Sheng Chen Tsai-Hung Wu Chung-Tei Chou Chang-Youh Tsai Hydrocephalus in an Elderly Man with Systemic Lupus Erythematosus Journal of the Formosan Medical Association antiphospholipid antibodies hydrocephalus neuropsychiatric systemic lupus erythematosus (NP-SLE) vasculitis |
author_facet |
Wei-Sheng Chen Tsai-Hung Wu Chung-Tei Chou Chang-Youh Tsai |
author_sort |
Wei-Sheng Chen |
title |
Hydrocephalus in an Elderly Man with Systemic Lupus Erythematosus |
title_short |
Hydrocephalus in an Elderly Man with Systemic Lupus Erythematosus |
title_full |
Hydrocephalus in an Elderly Man with Systemic Lupus Erythematosus |
title_fullStr |
Hydrocephalus in an Elderly Man with Systemic Lupus Erythematosus |
title_full_unstemmed |
Hydrocephalus in an Elderly Man with Systemic Lupus Erythematosus |
title_sort |
hydrocephalus in an elderly man with systemic lupus erythematosus |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2009-06-01 |
description |
A 71-year-old man presented with quadriplegia, seizures, dysarthria, motor aphasia and urinary incontinence lasting for several years. The development of proteinuria and increased susceptibility to infections brought the physician's attention to possible underlying autoimmune diseases. Laboratory investigations revealed evidence for systemic lupus erythematosus (SLE) and antiphospholipid syndrome. Imaging studies showed obstructive hydrocephalus. Several courses of methylprednisolone therapies followed by maintenance therapy with low-dose steroid, ventriculoperitoneal shunt, and antihypertensives improved the proteinuria and dysarthria but not the urinary incontinence or dementia. A thromboembolic event in the central nervous system secondary to phospholipid antibodies or lupus activity may represent a pathogenetic basis for hydrocephalus. When encountering a patient with hydrocephalus but without apparent predisposing factors, it is always important to include SLE as a differential diagnosis. |
topic |
antiphospholipid antibodies hydrocephalus neuropsychiatric systemic lupus erythematosus (NP-SLE) vasculitis |
url |
http://www.sciencedirect.com/science/article/pii/S0929664609601005 |
work_keys_str_mv |
AT weishengchen hydrocephalusinanelderlymanwithsystemiclupuserythematosus AT tsaihungwu hydrocephalusinanelderlymanwithsystemiclupuserythematosus AT chungteichou hydrocephalusinanelderlymanwithsystemiclupuserythematosus AT changyouhtsai hydrocephalusinanelderlymanwithsystemiclupuserythematosus |
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1725780246249078784 |