The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells

The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells

Cystinosin is a lysosomal transmembrane protein which facilitates transport of the disulphide amino acid cystine (CySS) from the lysosomes of the cell. This protein is encoded by the CTNS gene which is defective in the lysosomal storage disorder, cystinosis. Because of the apparent involvement of cy...

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Bibliographic Details
Main Authors: Rodolfo Sumayao, Philip Newsholme, Tara McMorrow
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Antioxidants
Subjects:
cystinosin
cystinosis
cysteine
cystine
cysteamine
glutathione
kidney
proximal tubule
lysosome
redox
thiol
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/7/12/179

Internet

https://www.mdpi.com/2076-3921/7/12/179

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