Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model

Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model

Background: Hypertrophic cardiomyopathy (HCM) patients often present with diastolic dysfunction and a normal to supranormal systolic function. To counteract this hypercontractility, guideline therapies advocate treatment with beta-adrenoceptor and Ca2+ channel blockers. One well established pathomec...

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Bibliographic Details
Main Authors: Sabrina Stücker, Nico Kresin, Lucie Carrier, Felix W. Friedrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Physiology
Subjects:
nebivolol
myofilament
Ca2+ sensitivity
hypertrophic cardiomyopathy
Mybpc3
mouse
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00558/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00558/full

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