Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components – Guidance of the inflammatory response as basis for osteochondral regeneration

Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components – Guidance of the inflammatory response as basis for osteochondral regeneration

The aim of the present study was the in vitro and in vivo analysis of a bi-layered 3D-printed scaffold combining a PLA layer and a biphasic PLA/bioglass G5 layer for regeneration of osteochondral defects in vivo Focus of the in vitro analysis was on the (molecular) weight loss and the morphological...

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Bibliographic Details
Main Authors: Mike Barbeck, Tiziano Serra, Patrick Booms, Sanja Stojanovic, Stevo Najman, Elisabeth Engel, Robert Sader, Charles James Kirkpatrick, Melba Navarro, Shahram Ghanaati
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-12-01
Series:Bioactive Materials
Subjects:
Bioactive glass
Polylactic acid (PLA)
Bi-layer scaffold
Multinucleated giant cells
Bone substitute
Vascularization
Calcium phosphate glass
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X1630055X

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http://www.sciencedirect.com/science/article/pii/S2452199X1630055X

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