A critical review of pro-cognitive drug targets in psychosis: Convergence on myelination and inflammation.

Antipsychotic drugs have thus far focused on dopaminergic antagonism at the D2 receptors, as counteracting the hyperdopaminergia in nigrostriatal and mesolimbic projections has been considered mandatory for the antipsychotic action of the drugs. Current drugs effectively target the positive symptoms...

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Bibliographic Details
Main Authors: Rune A. eKroken, Else-Marie eLøberg, Tore eDrønen, Renate eGruner, Kenneth eHugdahl, Kristiina eKompus, Silje eSkrede, Erik eJohnsen
Format: Article
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Psychiatry
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00011/full