Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus
Ulcerative colitis (UC) is 1 of the 2 major phenotypes of chronic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms that impair function and quality of life. Further, IBD often affects women during childbearing age. Indeed, UC ac...
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Korean Association for the Study of Intestinal Diseases
2018-07-01
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doaj-fb58477a816a471380c6b415e55d07062020-11-24T22:00:51ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562018-07-0116348448810.5217/ir.2018.16.3.484319Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimusTomoyoshi Shibuya0Keiichi Haga1Masato Kamei2Koki Okahara3Shoko Ito4Masahito Takahashi5Osamu Nomura6Takashi Murakami7Masae Makino8Tomohiro Kodani9Dai Ishikawa10Naoto Sakamoto11Taro Osada12Tatsuo Ogihara13Sumio Watanabe14Akihito Nagahara15Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, .JapanUlcerative colitis (UC) is 1 of the 2 major phenotypes of chronic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms that impair function and quality of life. Further, IBD often affects women during childbearing age. Indeed, UC activity frequently increases during pregnancy, and the medications used to induce remission may adversely affect the health of the mother and the unborn child. We report successful induction of a remission in a UC case who experienced a flare-up in the first trimester of pregnancy. Upon relapse, she was treated with steroids and adsorptive granulomonocytapheresis (GMA) with the Adacolumn plus tacrolimus. This combination therapy induced a stable remission that was maintained during her entire pregnancy. She gave birth to a healthy child at 36 weeks of pregnancy with no maternal or fetal complications. Our experience indicates that GMA, as a non-drug therapeutic intervention with a favorable safety profile, plus tacrolimus might be a relevant treatment option for patients with active IBD during pregnancy. A future study of a large cohort of pregnant patients should strengthen our findings.http://www.irjournal.org/upload/pdf/ir-16-484.pdfColitis, ulcerativePregnancyTacrolimusGranulomonocytapheresis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tomoyoshi Shibuya Keiichi Haga Masato Kamei Koki Okahara Shoko Ito Masahito Takahashi Osamu Nomura Takashi Murakami Masae Makino Tomohiro Kodani Dai Ishikawa Naoto Sakamoto Taro Osada Tatsuo Ogihara Sumio Watanabe Akihito Nagahara |
spellingShingle |
Tomoyoshi Shibuya Keiichi Haga Masato Kamei Koki Okahara Shoko Ito Masahito Takahashi Osamu Nomura Takashi Murakami Masae Makino Tomohiro Kodani Dai Ishikawa Naoto Sakamoto Taro Osada Tatsuo Ogihara Sumio Watanabe Akihito Nagahara Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus Intestinal Research Colitis, ulcerative Pregnancy Tacrolimus Granulomonocytapheresis |
author_facet |
Tomoyoshi Shibuya Keiichi Haga Masato Kamei Koki Okahara Shoko Ito Masahito Takahashi Osamu Nomura Takashi Murakami Masae Makino Tomohiro Kodani Dai Ishikawa Naoto Sakamoto Taro Osada Tatsuo Ogihara Sumio Watanabe Akihito Nagahara |
author_sort |
Tomoyoshi Shibuya |
title |
Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus |
title_short |
Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus |
title_full |
Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus |
title_fullStr |
Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus |
title_full_unstemmed |
Successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus |
title_sort |
successful remission of ulcerative colitis flare-up during pregnancy with adsorptive granulomonocytapheresis plus tacrolimus |
publisher |
Korean Association for the Study of Intestinal Diseases |
series |
Intestinal Research |
issn |
1598-9100 2288-1956 |
publishDate |
2018-07-01 |
description |
Ulcerative colitis (UC) is 1 of the 2 major phenotypes of chronic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms that impair function and quality of life. Further, IBD often affects women during childbearing age. Indeed, UC activity frequently increases during pregnancy, and the medications used to induce remission may adversely affect the health of the mother and the unborn child. We report successful induction of a remission in a UC case who experienced a flare-up in the first trimester of pregnancy. Upon relapse, she was treated with steroids and adsorptive granulomonocytapheresis (GMA) with the Adacolumn plus tacrolimus. This combination therapy induced a stable remission that was maintained during her entire pregnancy. She gave birth to a healthy child at 36 weeks of pregnancy with no maternal or fetal complications. Our experience indicates that GMA, as a non-drug therapeutic intervention with a favorable safety profile, plus tacrolimus might be a relevant treatment option for patients with active IBD during pregnancy. A future study of a large cohort of pregnant patients should strengthen our findings. |
topic |
Colitis, ulcerative Pregnancy Tacrolimus Granulomonocytapheresis |
url |
http://www.irjournal.org/upload/pdf/ir-16-484.pdf |
work_keys_str_mv |
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