Therapeutic potential of melatonin in oral medicine and periodontology
Melatonin (N-acetyl-5-methoxy tryptamine) is a substance secreted by multiple organs in vertebrates. In addition to playing a part in the circadian cycle of the body, melatonin is known to have antioxidant, antiinflammatory, and antioncotic effects on human tissues. Oral cavity is affected by a numb...
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doaj-fba19e589e40406e8048bbe19afe42852020-11-25T01:12:12ZengWileyKaohsiung Journal of Medical Sciences1607-551X2016-08-0132839139610.1016/j.kjms.2016.06.005Therapeutic potential of melatonin in oral medicine and periodontologyShariq Najeeb0Zohaib Khurshid1Sana Zohaib2Muhammad Sohail Zafar3Department of Dentistry, Riyadh Consultative Clinics, Imam Saud Road, Al Murooj, Riyadh, Saudi ArabiaDepartment of Dental Biomaterials, College of Dentistry, King Faisal University, Al-Hofuf, Saudi ArabiaDepartment of Biomedical Engineering, College of Engineering, King Faisal University, Al-Hofuf, Saudi ArabiaDepartment of Restorative Dentistry, College of Dentistry, Taibah University, Madina Munawwarah, Saudi ArabiaMelatonin (N-acetyl-5-methoxy tryptamine) is a substance secreted by multiple organs in vertebrates. In addition to playing a part in the circadian cycle of the body, melatonin is known to have antioxidant, antiinflammatory, and antioncotic effects on human tissues. Oral cavity is affected by a number of conditions such as periodontitis, mucositis, cancers, and cytotoxicity from various drugs or biomaterials. Research has suggested that melatonin is effective in treating the aforementioned pathologies. Furthermore, melatonin has been observed to enhance osseointegration and bone regeneration. The aim of this review is to critically analyze and summarize the research focusing on the potential of melatonin in the field of oral medicine. Topical administration of melatonin has a positive effect on periodontal health and osseointegration. Furthermore, melatonin is particularly effective in improving the periodontal parameters of diabetic patients with periodontitis. Melatonin exerts a regenerative effect on periodontal bone and may be incorporated into of periodontal scaffolds. The cytotoxic effect of various drugs and dental materials may be countered by the antioxidant properties of melatonin. Topical administration of melatonin promotes the healing of tooth extraction sockets and may also impede the progression of oral cancer. Although, there are a number of current and potential applications of melatonin, further long term clinical and animal studies are needed to assess its efficacy. Moreover, the role of melatonin supplements in the management of periodontitis should also be assessed.http://www.sciencedirect.com/science/article/pii/S1607551X16301012AntioxidantsMelatoninOral cancerOsseointegrationPeriodontitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shariq Najeeb Zohaib Khurshid Sana Zohaib Muhammad Sohail Zafar |
spellingShingle |
Shariq Najeeb Zohaib Khurshid Sana Zohaib Muhammad Sohail Zafar Therapeutic potential of melatonin in oral medicine and periodontology Kaohsiung Journal of Medical Sciences Antioxidants Melatonin Oral cancer Osseointegration Periodontitis |
author_facet |
Shariq Najeeb Zohaib Khurshid Sana Zohaib Muhammad Sohail Zafar |
author_sort |
Shariq Najeeb |
title |
Therapeutic potential of melatonin in oral medicine and periodontology |
title_short |
Therapeutic potential of melatonin in oral medicine and periodontology |
title_full |
Therapeutic potential of melatonin in oral medicine and periodontology |
title_fullStr |
Therapeutic potential of melatonin in oral medicine and periodontology |
title_full_unstemmed |
Therapeutic potential of melatonin in oral medicine and periodontology |
title_sort |
therapeutic potential of melatonin in oral medicine and periodontology |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X |
publishDate |
2016-08-01 |
description |
Melatonin (N-acetyl-5-methoxy tryptamine) is a substance secreted by multiple organs in vertebrates. In addition to playing a part in the circadian cycle of the body, melatonin is known to have antioxidant, antiinflammatory, and antioncotic effects on human tissues. Oral cavity is affected by a number of conditions such as periodontitis, mucositis, cancers, and cytotoxicity from various drugs or biomaterials. Research has suggested that melatonin is effective in treating the aforementioned pathologies. Furthermore, melatonin has been observed to enhance osseointegration and bone regeneration. The aim of this review is to critically analyze and summarize the research focusing on the potential of melatonin in the field of oral medicine. Topical administration of melatonin has a positive effect on periodontal health and osseointegration. Furthermore, melatonin is particularly effective in improving the periodontal parameters of diabetic patients with periodontitis. Melatonin exerts a regenerative effect on periodontal bone and may be incorporated into of periodontal scaffolds. The cytotoxic effect of various drugs and dental materials may be countered by the antioxidant properties of melatonin. Topical administration of melatonin promotes the healing of tooth extraction sockets and may also impede the progression of oral cancer. Although, there are a number of current and potential applications of melatonin, further long term clinical and animal studies are needed to assess its efficacy. Moreover, the role of melatonin supplements in the management of periodontitis should also be assessed. |
topic |
Antioxidants Melatonin Oral cancer Osseointegration Periodontitis |
url |
http://www.sciencedirect.com/science/article/pii/S1607551X16301012 |
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AT shariqnajeeb therapeuticpotentialofmelatonininoralmedicineandperiodontology AT zohaibkhurshid therapeuticpotentialofmelatonininoralmedicineandperiodontology AT sanazohaib therapeuticpotentialofmelatonininoralmedicineandperiodontology AT muhammadsohailzafar therapeuticpotentialofmelatonininoralmedicineandperiodontology |
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