Nav1.5 cardiac sodium channels, regulation and clinical implications
Voltage-gated sodium channels constitute a group of membrane proteins widely distributed thought the body. In the heart, there are at least six different isoforms, being the Nav1.5 the most abundant. The channel is composed of an α subunit that is formed by four domains of six segments each, and fou...
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doaj-fbafec07e36147b4b8b2854c00c38e252020-11-24T22:48:01ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482014-10-0162458759210.15446/revfacmed.v62n4.4401539908Nav1.5 cardiac sodium channels, regulation and clinical implicationsHenry Humberto León Ariza0Natalia Valenzuela Faccini1Ariana Carolina Rojas Ortega2Daniel Alfonso Botero Rosas3Universidad de La Sabana, Fundación Universitaria SanitasUniversidad de La SabanaUniversidad de La SabanaUniversidad de La Sabana, Universidad Antonio NariñoVoltage-gated sodium channels constitute a group of membrane proteins widely distributed thought the body. In the heart, there are at least six different isoforms, being the Nav1.5 the most abundant. The channel is composed of an α subunit that is formed by four domains of six segments each, and four much smaller β subunits that provide stability and integrate other channels into the α subunit. The function of the Nav1.5 channel is modulated by intracellular cytoskeleton proteins, extracellular proteins, calcium concentration, free radicals, and medications, among other things. The study of the channel and its alterations has grown thanks to its association with pathogenic conditions such as Long QT syndrome, Brugada syndrome, atrial fibrillation, arrhythmogenic ventricular dysplasia and complications during ischemic processes.https://revistas.unal.edu.co/index.php/revfacmed/article/view/44015Canales de SodioSíndrome QT largoSíndrome Brugada |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Henry Humberto León Ariza Natalia Valenzuela Faccini Ariana Carolina Rojas Ortega Daniel Alfonso Botero Rosas |
spellingShingle |
Henry Humberto León Ariza Natalia Valenzuela Faccini Ariana Carolina Rojas Ortega Daniel Alfonso Botero Rosas Nav1.5 cardiac sodium channels, regulation and clinical implications Revista de la Facultad de Medicina Canales de Sodio Síndrome QT largo Síndrome Brugada |
author_facet |
Henry Humberto León Ariza Natalia Valenzuela Faccini Ariana Carolina Rojas Ortega Daniel Alfonso Botero Rosas |
author_sort |
Henry Humberto León Ariza |
title |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
title_short |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
title_full |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
title_fullStr |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
title_full_unstemmed |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
title_sort |
nav1.5 cardiac sodium channels, regulation and clinical implications |
publisher |
Universidad Nacional de Colombia |
series |
Revista de la Facultad de Medicina |
issn |
0120-0011 2357-3848 |
publishDate |
2014-10-01 |
description |
Voltage-gated sodium channels constitute a group of membrane
proteins widely distributed thought the body. In the heart, there
are at least six different isoforms, being the Nav1.5 the most
abundant. The channel is composed of an α subunit that is formed
by four domains of six segments each, and four much smaller β
subunits that provide stability and integrate other channels into
the α subunit. The function of the Nav1.5 channel is modulated
by intracellular cytoskeleton proteins, extracellular proteins,
calcium concentration, free radicals, and medications, among
other things. The study of the channel and its alterations has
grown thanks to its association with pathogenic conditions such
as Long QT syndrome, Brugada syndrome, atrial fibrillation,
arrhythmogenic ventricular dysplasia and complications during
ischemic processes. |
topic |
Canales de Sodio Síndrome QT largo Síndrome Brugada |
url |
https://revistas.unal.edu.co/index.php/revfacmed/article/view/44015 |
work_keys_str_mv |
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1725680050268798976 |