PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1.

PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1.

Akt, a serine/threonine kinase has been shown to stimulate glycolysis in cancer cells but its role in mitochondrial respiration is unknown. Using PTEN-knockout mouse embryonic fibroblasts (MEF(PTEN-/-)) with hyper-activated Akt as a cell model, we observed a higher respiratory capacity in MEF(PTEN-/...

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Bibliographic Details
Main Authors: Chong Kiat Goo, Hwee Ying Lim, Qin Shi Ho, Heng-Phon Too, Marie-Veronique Clement, Kim Ping Wong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458951?pdf=render

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http://europepmc.org/articles/PMC3458951?pdf=render

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