Endocrine disruptors and congenital anomalies

The specialized literature was reviewed concerning the suspected increasing secular trends in the frequency of female births, male genital congenital anomalies, abnormal sperm counts, and testicular cancer. Although no risk factors could be identified yet, the observed sex ratio decline during the l...

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Bibliographic Details
Main Authors: Mônica Rittler, Eduardo E. Castilla
Format: Article
Language:English
Published: Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
Series:Cadernos de Saúde Pública
Subjects:
Online Access:http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X2002000200006&lng=en&tlng=en
Description
Summary:The specialized literature was reviewed concerning the suspected increasing secular trends in the frequency of female births, male genital congenital anomalies, abnormal sperm counts, and testicular cancer. Although no risk factors could be identified yet, the observed sex ratio decline during the last decades has been considered to be an effect of certain pollutants on normal hormone activity, and human reproductive development. Reported increasing trends in the frequencies of hypospadias and cryptorchidism are very difficult to be interpreted due to the large variability in the registered frequency of these malformations due to operational as well as biological reasons.
ISSN:0102-311X
1678-4464