Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.

Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.

Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) at Thr...

Full description

Bibliographic Details
Main Authors:	Yukio eYamamura, Ryoma eMorigaki, Jiro eKasahara, Hironori eYokoyama, Akie eTanabe, Shinya eOkita, Hidetaka eKoizumi, Shinji eNagahiro, Ryuji eKaji, Satoshi eGoto
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-02-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	Cyclin-Dependent Kinase 5 Dopamine Phosphorylation Striatum Cell signaling
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00012/full

Similar Items

A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson’s disease.
by: Akie eTanabe, et al.
Published: (2014-02-01)

Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson’s disease: a potential compensatory role.
by: Hidetaka eKoizumi, et al.
Published: (2013-05-01)

Development of a highly sensitive immunohistochemical method to detect neurochemical molecules in formalin-fixed and paraffin-embedded tissues from autopsied human brains
by: Satoshi eGoto, et al.
Published: (2015-03-01)

Spinal central effects of peripherally applied botulinum neurotoxin A in comparison between its subtypes A1 and A2
by: Hidetaka eKoizumi, et al.
Published: (2014-06-01)

Putaminal mosaic visualized by tyrosine hydroxylase immunohistochemistry in the human neostriatum.
by: Ryoma eMorigaki, et al.
Published: (2016-04-01)

Postsynaptic density protein 95 in the striosome and matrix compartments of the human neostriatum.
by: Ryoma eMorigaki, et al.
Published: (2015-11-01)

Quantification of viral infection dynamics in animal experiments
by: Shingo eIwami, et al.
Published: (2013-09-01)

Efficacy of zolpidem for dystonia: a study among different subtypes
by: Yoshimichi eMiyazaki, et al.
Published: (2012-04-01)

Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration.
by: Isao eIshii, et al.
Published: (2012-10-01)

Clinicopathological Phenotype and Genetics of X-Linked Dystonia–Parkinsonism (XDP; DYT3; Lubag)
by: Toshitaka Kawarai, et al.
Published: (2017-06-01)

The processing cost of scrambling and topicalization in Japanese
by: Satoshi eImamura, et al.
Published: (2016-04-01)

Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
by: Ryoma Morigaki, et al.
Published: (2017-06-01)

Role of the oxytocin receptor expressed in the rostral medullary raphe in thermoregulation during cold conditions
by: Yoshiyuki eKasahara, et al.
Published: (2015-11-01)

Screening for the genes involved in bombykol biosynthesis: Identification and functional characterization of Bombyx mori acyl carrier protein (BmACP)
by: Atsushi eOhnishi, et al.
Published: (2011-12-01)

Role of intrapancreatic SPINK1/Spink3 expression in the development of pancreatitis
by: Masaki eOhmuraya, et al.
Published: (2012-05-01)

Raise two effects with one scene: Scene contexts have two separate effects in visual working memory of target faces.
by: Azumi eTanabe-Ishibashi, et al.
Published: (2014-05-01)

The extract of roots of Sophora flavescens enhances the recovery of motor function by axonal growth in mice with a spinal cord injury
by: Norio eTanabe, et al.
Published: (2016-01-01)

Impaired axonal Na+ current by hindlimb unloading: implication for disuse neuromuscular atrophy
by: Chimeglkham eBanzrai, et al.
Published: (2016-02-01)

A small RNA mediated regulation of a stress-activated retrotransposon and the tissue specific transposition during the reproductive period in Arabidopsis
by: Wataru eMatsunaga, et al.
Published: (2015-02-01)

The development of the effect of peer monitoring on generosity differs among elementary school-age boys and girls
by: Haruto eTakagishi, et al.
Published: (2015-06-01)

Functional lateralization of speech processing in adults and children who stutter
by: Yutaka eSato, et al.
Published: (2011-04-01)

New mitotic regulators released from chromatin
by: Hideki eYokoyama, et al.
Published: (2013-12-01)

Changes in the spinal neural circuits are dependent on the movement speed of the visuomotor task
by: Shinji eKubota, et al.
Published: (2015-12-01)

Ghrelin receptor in two species of anuran amphibian, bullfrog (Rana catesbeiana) and Japanese tree frog (Hyla japonica)
by: Hiroyuki eKaiya, et al.
Published: (2011-09-01)

Identification and localization of a neuron-specific isoform of TAF1 in rat brain: implications for neuropathology of DYT3 dystonia
by: Sako, W., et al.
Published: (2016)

Reward learning and negative emotion during rapid attentional competition
by: Takemasa eYokoyama, et al.
Published: (2015-03-01)

Genomics and computational science for virus research
by: Hironori eSato, et al.
Published: (2013-03-01)

PKA modulation of Rac in neuronal cells
by: Akihiro eGoto, et al.
Published: (2014-10-01)

Enhancement of electricity production by graphene oxide in soil microbial fuel cells and plant microbial fuel cells
by: Yuko eGoto, et al.
Published: (2015-04-01)

Neural substrates underlying reconcentration for the preparation of an appropriate cognitive state to prevent future mistakes: A functional magnetic resonance imaging study
by: Naoki eMiura, et al.
Published: (2015-11-01)

Fragments of target cells are internalized into retroviral envelope protein-expressing cells during cell-cell fusion by endocytosis
by: Mai eIzumida, et al.
Published: (2016-01-01)

Murine depression model and its potential applications for discovering foods and farm products with antidepressant-like effects
by: Tatsuhiko eGoto, et al.
Published: (2016-03-01)

Dopamine in Socioecological and Evolutionary Perspectives: Implications for Psychiatric Disorders
by: Yoshie eYamaguchi, et al.
Published: (2015-06-01)

Are plasma oxytocin and vasopressin levels reflective of amygdala activation during the processing of negative emotions? A preliminary study
by: Kosuke eMotoki, et al.
Published: (2016-04-01)

Influence of low- and high-elevation plant genomes on the regulation of autumn cold acclimation in Abies sachalinensis
by: Wataru eIshizuka, et al.
Published: (2015-10-01)

A critical role of holistic processing in face gender perception
by: Takemasa eYokoyama, et al.
Published: (2014-06-01)

Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance
by: Toru eHosoi, et al.
Published: (2012-01-01)

Lateralized frontal activity for Japanese phonological processing during child development
by: Takaaki eGoto, et al.
Published: (2015-07-01)

An engineered lipid remodeling system using a galactolipid synthase promoter during phosphate starvation enhances oil accumulation in plants
by: Mie eShimojima, et al.
Published: (2015-08-01)

Vacuolar processing enzyme in plant programmed cell death
by: Noriyuki eHatsugai, et al.
Published: (2015-04-01)