Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies.

Identifying optimal dosing of antibiotics has proven challenging-some antibiotics are most effective when they are administered periodically at high doses, while others work best when minimizing concentration fluctuations. Mechanistic explanations for why antibiotics differ in their optimal dosing a...

Full description

Bibliographic Details
Main Authors: Pia Abel Zur Wiesch, Fabrizio Clarelli, Ted Cohen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1005321