Cell-cell fusion induced by reovirus FAST proteins enhances replication and pathogenicity of non-enveloped dsRNA viruses.

Cell-cell fusion induced by reovirus FAST proteins enhances replication and pathogenicity of non-enveloped dsRNA viruses.

Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known. We generated replication-competent, FAST protein-deficient...

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Bibliographic Details
Main Authors: Yuta Kanai, Takahiro Kawagishi, Yusuke Sakai, Ryotaro Nouda, Masayuki Shimojima, Masayuki Saijo, Yoshiharu Matsuura, Takeshi Kobayashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007675

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https://doi.org/10.1371/journal.ppat.1007675

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