Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion

Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion

Disruption of the blood-brain barrier (BBB) and the subsequent formation of brain edema is the most severe consequence of intracerebral hemorrhage (ICH), leading to drastic neuroinflammatory responses and neuronal cell death. A better understanding of ICH pathophysiology to develop effective therapy...

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Bibliographic Details
Main Authors: Peijun Jia, Jinxin He, Zefu Li, Junmin Wang, Lin Jia, Ruochen Hao, Jonathan Lai, Weidong Zang, Xuemei Chen, Jian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
intracerebral hemorrhage
collagenase
autologous blood
blood-brain barrier
tight junction
aquaporin 4
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.699736/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.699736/full

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