Environmental enrichment intervention for Rett syndrome: an individually randomised stepped wedge trial

Environmental enrichment intervention for Rett syndrome: an individually randomised stepped wedge trial

Abstract Background Rett syndrome is caused by a pathogenic mutation in the MECP2 gene with major consequences for motor and cognitive development. One of the effects of impaired MECP2 function is reduced production of Brain Derived Neurotrophic Factor (BDNF), a protein required for normal neuronal...

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Bibliographic Details
Main Authors: Jenny Downs, Jenny Rodger, Chen Li, Xuesong Tan, Nan Hu, Kingsley Wong, Nicholas de Klerk, Helen Leonard
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Rett syndrome
Neurodevelopmental disorder
Environmental enrichment
Neuroplasticity
BDNF
Online Access:http://link.springer.com/article/10.1186/s13023-017-0752-8

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http://link.springer.com/article/10.1186/s13023-017-0752-8

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