Stem Cell Transplantation in Iran: A Systematic Review Article
Background: Stem cell therapy is a new treatment option for different diseases. The aim of this systematic review is assessing the articles that focus on SCT in Iran and evaluate the amount of their success, failure and complication. Methods: Systematic search was conducted for finding English and...
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Tehran University of Medical Sciences
2015-10-01
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doaj-fcb2df23141f468fb3bf4fe4de6c796c2020-12-02T18:52:06ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932015-10-0144Supple 24700Stem Cell Transplantation in Iran: A Systematic Review ArticleRowshanak ABBASIBagher LARIJANIEnsieh NASLI ESFAHANIMostafa GHORBANICamelia RAMBODRamin HESHMAT Background: Stem cell therapy is a new treatment option for different diseases. The aim of this systematic review is assessing the articles that focus on SCT in Iran and evaluate the amount of their success, failure and complication. Methods: Systematic search was conducted for finding English and Persian papers (controlled trials and cohort studies with follow up) published before March 2015. We searched PubMed, ISI, and SCOPUS as the main international electronic data sources, as well as Iranmedex, Irandoc, andSID as the main domestic databases. Quality assessment of clinical trial and cohort study was performed based on the Consolidated Standards of Reporting Trials (CONSORT) and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) check lists respectively. Results: The 19 published articles in this systematic review included 2 cohort, 13 clinical trial, 3 open label clinical trial and 1 clinical trial pilot study. The stem cell types for transplantation were Mesenchymal (63.15%), mononuclear (31.6%), and fetal liver cell suspension (5.6%). The most SCT was performed at Tehran (68.42%), Shiraz (15.8%), Kerman & Isfahan hospitals (5.26%). The main diseases were decompensated cirrhosis and myocardial infarction (26.31%), MS (15.78%), DM (10.52%), Burger disease, neuroblastoma, sub-acute spinal cord injury and osteoarthritis (5.26%). Conclusion: The most of cells transplantation are performed successfully in Iran. Cell transplantation may be safely administered to treat patients with disabling disease. Keywords: Clinical Trial, Cohort, Stem Cell Transplantation, Iran https://ijph.tums.ac.ir/index.php/ijph/article/view/4910 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rowshanak ABBASI Bagher LARIJANI Ensieh NASLI ESFAHANI Mostafa GHORBANI Camelia RAMBOD Ramin HESHMAT |
spellingShingle |
Rowshanak ABBASI Bagher LARIJANI Ensieh NASLI ESFAHANI Mostafa GHORBANI Camelia RAMBOD Ramin HESHMAT Stem Cell Transplantation in Iran: A Systematic Review Article Iranian Journal of Public Health |
author_facet |
Rowshanak ABBASI Bagher LARIJANI Ensieh NASLI ESFAHANI Mostafa GHORBANI Camelia RAMBOD Ramin HESHMAT |
author_sort |
Rowshanak ABBASI |
title |
Stem Cell Transplantation in Iran: A Systematic Review Article |
title_short |
Stem Cell Transplantation in Iran: A Systematic Review Article |
title_full |
Stem Cell Transplantation in Iran: A Systematic Review Article |
title_fullStr |
Stem Cell Transplantation in Iran: A Systematic Review Article |
title_full_unstemmed |
Stem Cell Transplantation in Iran: A Systematic Review Article |
title_sort |
stem cell transplantation in iran: a systematic review article |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Public Health |
issn |
2251-6085 2251-6093 |
publishDate |
2015-10-01 |
description |
Background: Stem cell therapy is a new treatment option for different diseases. The aim of this systematic review is assessing the articles that focus on SCT in Iran and evaluate the amount of their success, failure and complication.
Methods: Systematic search was conducted for finding English and Persian papers (controlled trials and cohort studies with follow up) published before March 2015. We searched PubMed, ISI, and SCOPUS as the main international electronic data sources, as well as Iranmedex, Irandoc, andSID as the main domestic databases. Quality assessment of clinical trial and cohort study was performed based on the Consolidated Standards of Reporting Trials (CONSORT) and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) check lists respectively.
Results: The 19 published articles in this systematic review included 2 cohort, 13 clinical trial, 3 open label clinical trial and 1 clinical trial pilot study. The stem cell types for transplantation were Mesenchymal (63.15%), mononuclear (31.6%), and fetal liver cell suspension (5.6%). The most SCT was performed at Tehran (68.42%), Shiraz (15.8%), Kerman & Isfahan hospitals (5.26%). The main diseases were decompensated cirrhosis and myocardial infarction (26.31%), MS (15.78%), DM (10.52%), Burger disease, neuroblastoma, sub-acute spinal cord injury and osteoarthritis (5.26%).
Conclusion: The most of cells transplantation are performed successfully in Iran. Cell transplantation may be safely administered to treat patients with disabling disease.
Keywords: Clinical Trial, Cohort, Stem Cell Transplantation, Iran
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url |
https://ijph.tums.ac.ir/index.php/ijph/article/view/4910 |
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