Stem Cell Transplantation in Iran: A Systematic Review Article

Background: Stem cell therapy is a new treatment option for different diseases. The aim of this systematic review is assessing the articles that focus on SCT in Iran and evaluate the amount of their success, failure and complication. Methods: Systematic search was conducted for finding English and...

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Main Authors: Rowshanak ABBASI, Bagher LARIJANI, Ensieh NASLI ESFAHANI, Mostafa GHOR­BANI, Camelia RAMBOD, Ramin HESHMAT
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2015-10-01
Series:Iranian Journal of Public Health
Online Access:https://ijph.tums.ac.ir/index.php/ijph/article/view/4910
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spelling doaj-fcb2df23141f468fb3bf4fe4de6c796c2020-12-02T18:52:06ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932015-10-0144Supple 24700Stem Cell Transplantation in Iran: A Systematic Review ArticleRowshanak ABBASIBagher LARIJANIEnsieh NASLI ESFAHANIMostafa GHOR­BANICamelia RAMBODRamin HESHMAT Background: Stem cell therapy is a new treatment option for different diseases. The aim of this systematic review is assessing the articles that focus on SCT in Iran and evaluate the amount of their success, failure and complication. Methods: Systematic search was conducted for finding English and Persian papers (controlled trials and cohort studies with follow up) published before March 2015. We searched PubMed, ISI, and SCOPUS as the main international electronic data sources, as well as Iranmedex, Irandoc, andSID as the main domestic databases. Quality assessment of clinical trial and cohort study was performed based on the Consolidated Standards of Reporting Trials (CONSORT) and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) check lists respectively. Results: The 19 published articles in this systematic review included 2 cohort, 13 clinical trial, 3 open label clinical trial and 1 clinical trial pilot study. The stem cell types for transplantation were Mesenchymal (63.15%), mononuclear (31.6%), and fetal liver cell suspension (5.6%). The most SCT was performed at Tehran (68.42%), Shiraz (15.8%), Kerman & Isfahan hospitals (5.26%). The main diseases were decompensated cirrhosis and myocardial infarction (26.31%), MS (15.78%), DM (10.52%), Burger disease, neuroblastoma, sub-acute spinal cord injury and osteoarthritis (5.26%). Conclusion: The most of cells transplantation are performed successfully in Iran. Cell transplantation may be safely administered to treat patients with disabling disease.   Keywords: Clinical Trial, Cohort, Stem Cell Transplantation, Iran https://ijph.tums.ac.ir/index.php/ijph/article/view/4910
collection DOAJ
language English
format Article
sources DOAJ
author Rowshanak ABBASI
Bagher LARIJANI
Ensieh NASLI ESFAHANI
Mostafa GHOR­BANI
Camelia RAMBOD
Ramin HESHMAT
spellingShingle Rowshanak ABBASI
Bagher LARIJANI
Ensieh NASLI ESFAHANI
Mostafa GHOR­BANI
Camelia RAMBOD
Ramin HESHMAT
Stem Cell Transplantation in Iran: A Systematic Review Article
Iranian Journal of Public Health
author_facet Rowshanak ABBASI
Bagher LARIJANI
Ensieh NASLI ESFAHANI
Mostafa GHOR­BANI
Camelia RAMBOD
Ramin HESHMAT
author_sort Rowshanak ABBASI
title Stem Cell Transplantation in Iran: A Systematic Review Article
title_short Stem Cell Transplantation in Iran: A Systematic Review Article
title_full Stem Cell Transplantation in Iran: A Systematic Review Article
title_fullStr Stem Cell Transplantation in Iran: A Systematic Review Article
title_full_unstemmed Stem Cell Transplantation in Iran: A Systematic Review Article
title_sort stem cell transplantation in iran: a systematic review article
publisher Tehran University of Medical Sciences
series Iranian Journal of Public Health
issn 2251-6085
2251-6093
publishDate 2015-10-01
description Background: Stem cell therapy is a new treatment option for different diseases. The aim of this systematic review is assessing the articles that focus on SCT in Iran and evaluate the amount of their success, failure and complication. Methods: Systematic search was conducted for finding English and Persian papers (controlled trials and cohort studies with follow up) published before March 2015. We searched PubMed, ISI, and SCOPUS as the main international electronic data sources, as well as Iranmedex, Irandoc, andSID as the main domestic databases. Quality assessment of clinical trial and cohort study was performed based on the Consolidated Standards of Reporting Trials (CONSORT) and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) check lists respectively. Results: The 19 published articles in this systematic review included 2 cohort, 13 clinical trial, 3 open label clinical trial and 1 clinical trial pilot study. The stem cell types for transplantation were Mesenchymal (63.15%), mononuclear (31.6%), and fetal liver cell suspension (5.6%). The most SCT was performed at Tehran (68.42%), Shiraz (15.8%), Kerman & Isfahan hospitals (5.26%). The main diseases were decompensated cirrhosis and myocardial infarction (26.31%), MS (15.78%), DM (10.52%), Burger disease, neuroblastoma, sub-acute spinal cord injury and osteoarthritis (5.26%). Conclusion: The most of cells transplantation are performed successfully in Iran. Cell transplantation may be safely administered to treat patients with disabling disease.   Keywords: Clinical Trial, Cohort, Stem Cell Transplantation, Iran
url https://ijph.tums.ac.ir/index.php/ijph/article/view/4910
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AT bagherlarijani stemcelltransplantationiniranasystematicreviewarticle
AT ensiehnasliesfahani stemcelltransplantationiniranasystematicreviewarticle
AT mostafaghorbani stemcelltransplantationiniranasystematicreviewarticle
AT cameliarambod stemcelltransplantationiniranasystematicreviewarticle
AT raminheshmat stemcelltransplantationiniranasystematicreviewarticle
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