Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism

Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism

Abstract Background Statins are a class of therapeutics used to regulate serum cholesterol and reduce the risk of heart disease. Although statins are highly effective in removing cholesterol from the blood, their consumption has been linked to potential adverse effects in some individuals. The most...

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Bibliographic Details
Main Authors: Jose A. Caparrós-Martín, Ricky R. Lareu, Joshua P. Ramsay, Jörg Peplies, F. Jerry Reen, Henrietta A. Headlam, Natalie C. Ward, Kevin D. Croft, Philip Newsholme, Jeffery D. Hughes, Fergal O’Gara
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Microbiome
Subjects:
Statins
Gut microbiota
Dysbiosis
Bile acids
Short-chain fatty acids
Type 2 diabetes mellitus
Online Access:http://link.springer.com/article/10.1186/s40168-017-0312-4

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http://link.springer.com/article/10.1186/s40168-017-0312-4

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