Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia
Abstract Emerging evidences addressed an association between phosphate and muscle function. Because little attention was focused on this issue, the objective of our study was to explore the relationship of phosphate with muscle strength, dynapenia, and sarcopenia. From the National Health and Nutrit...
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doaj-fccec3de7ea542578a719aa26f9ce70d2020-12-08T03:55:15ZengNature Publishing GroupScientific Reports2045-23222018-02-01811910.1038/s41598-018-21784-1Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and SarcopeniaYuan-Yuei Chen0Tung-Wei Kao1Cheng-Wai Chou2Chen-Jung Wu3Hui-Fang Yang4Ching-Huang Lai5Li-Wei Wu6Wei-Liang Chen7Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, School of Medicine, National Defense Medical CenterDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical CenterDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical CenterDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical CenterDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical CenterSchool of Public Health, National Defense Medical CenterDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical CenterDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical CenterAbstract Emerging evidences addressed an association between phosphate and muscle function. Because little attention was focused on this issue, the objective of our study was to explore the relationship of phosphate with muscle strength, dynapenia, and sarcopenia. From the National Health and Nutrition Examination Survey, a total of 7421 participants aged 20 years or older were included in our study with comprehensive examinations included anthropometric parameters, strength of the quadriceps muscle, and appendicular lean masses. Within the normal range of serum phosphate, we used quartile-based analyses to determine the potential relationships of serum phosphate with dynapenia, and sarcopenia through multivariate regression models. After adjusting for the pertinent variables, an inverse association between the serum phosphate quartiles and muscle strength was observed and the linear association was stronger than other anthropometric parameters. Notably, the significant association between phosphate and muscle strength was existed in >65 years old age group, not in 20–65 years old. The higher quartiles of phosphate had higher likelihood for predicting the presence of dynapenia rather than sarcopenia in entire population. Our study highlighted that higher quartiles of phosphate had significant association with lower muscle strength and higher risks for predicting the presence of dynapenia.https://doi.org/10.1038/s41598-018-21784-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuan-Yuei Chen Tung-Wei Kao Cheng-Wai Chou Chen-Jung Wu Hui-Fang Yang Ching-Huang Lai Li-Wei Wu Wei-Liang Chen |
spellingShingle |
Yuan-Yuei Chen Tung-Wei Kao Cheng-Wai Chou Chen-Jung Wu Hui-Fang Yang Ching-Huang Lai Li-Wei Wu Wei-Liang Chen Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia Scientific Reports |
author_facet |
Yuan-Yuei Chen Tung-Wei Kao Cheng-Wai Chou Chen-Jung Wu Hui-Fang Yang Ching-Huang Lai Li-Wei Wu Wei-Liang Chen |
author_sort |
Yuan-Yuei Chen |
title |
Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia |
title_short |
Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia |
title_full |
Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia |
title_fullStr |
Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia |
title_full_unstemmed |
Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia |
title_sort |
exploring the link between serum phosphate levels and low muscle strength, dynapenia, and sarcopenia |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2018-02-01 |
description |
Abstract Emerging evidences addressed an association between phosphate and muscle function. Because little attention was focused on this issue, the objective of our study was to explore the relationship of phosphate with muscle strength, dynapenia, and sarcopenia. From the National Health and Nutrition Examination Survey, a total of 7421 participants aged 20 years or older were included in our study with comprehensive examinations included anthropometric parameters, strength of the quadriceps muscle, and appendicular lean masses. Within the normal range of serum phosphate, we used quartile-based analyses to determine the potential relationships of serum phosphate with dynapenia, and sarcopenia through multivariate regression models. After adjusting for the pertinent variables, an inverse association between the serum phosphate quartiles and muscle strength was observed and the linear association was stronger than other anthropometric parameters. Notably, the significant association between phosphate and muscle strength was existed in >65 years old age group, not in 20–65 years old. The higher quartiles of phosphate had higher likelihood for predicting the presence of dynapenia rather than sarcopenia in entire population. Our study highlighted that higher quartiles of phosphate had significant association with lower muscle strength and higher risks for predicting the presence of dynapenia. |
url |
https://doi.org/10.1038/s41598-018-21784-1 |
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