Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing

The biggest challenge in the present-day healthcare scenario is the rapid emergence and spread of antimicrobial resistance due to the rampant use of antibiotics in daily therapeutics. Such drug resistance is associated with the enhancement of microbial virulence and the acquisition of the ability to...

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Main Authors: Moupriya Nag, Dibyajit Lahiri, Dipro Mukherjee, Ritwik Banerjee, Sayantani Garai, Tanmay Sarkar, Sujay Ghosh, Ankita Dey, Sougata Ghosh, Smaranika Pattnaik, Hisham Atan Edinur, Zulhisyam Abdul Kari, Siddhartha Pati, Rina Rani Ray
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Polymers
Subjects:
Online Access:https://www.mdpi.com/2073-4360/13/15/2533
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spelling doaj-fcfa4ac188354ff0a2123b295e0644642021-08-06T15:30:07ZengMDPI AGPolymers2073-43602021-07-01132533253310.3390/polym13152533Functionalized Chitosan Nanomaterials: A Jammer for Quorum SensingMoupriya Nag0Dibyajit Lahiri1Dipro Mukherjee2Ritwik Banerjee3Sayantani Garai4Tanmay Sarkar5Sujay Ghosh6Ankita Dey7Sougata Ghosh8Smaranika Pattnaik9Hisham Atan Edinur10Zulhisyam Abdul Kari11Siddhartha Pati12Rina Rani Ray13Department of Biotechnology, University of Engineering & Management, Kolkata 700160, IndiaDepartment of Biotechnology, University of Engineering & Management, Kolkata 700160, IndiaDepartment of Biotechnology, University of Engineering & Management, Kolkata 700160, IndiaDepartment of Biotechnology, University of Engineering & Management, Kolkata 700160, IndiaDepartment of Biotechnology, University of Engineering & Management, Kolkata 700160, IndiaDepartment of Food Technology and Bio-Chemical Engineering, Jadavpur University, Kolkata 700032, IndiaAMH Energy Pvt. Ltd., Kolkata 700039, IndiaDepartment of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata 741249, IndiaDepartment of Microbiology, School of Science, RK. University, Rajkot 360020, IndiaDepartment of Biotechnology and Bioinformatics, Sambalpur University, Odishsa 768001, IndiaSchool of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan 16150, MalaysiaFaculty of Agro Based Industry, Universiti Malaysia Kelantan, Kota Bharu 17600, MalaysiaCentre of Excellence, Khallikote University, Berhampur 761008, IndiaDepartment of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata 741249, IndiaThe biggest challenge in the present-day healthcare scenario is the rapid emergence and spread of antimicrobial resistance due to the rampant use of antibiotics in daily therapeutics. Such drug resistance is associated with the enhancement of microbial virulence and the acquisition of the ability to evade the host’s immune response under the shelter of a biofilm. Quorum sensing (QS) is the mechanism by which the microbial colonies in a biofilm modulate and intercept communication without direct interaction. Hence, the eradication of biofilms through hindering this communication will lead to the successful management of drug resistance and may be a novel target for antimicrobial chemotherapy. Chitosan shows microbicidal activities by acting electrostatically with its positively charged amino groups, which interact with anionic moieties on microbial species, causing enhanced membrane permeability and eventual cell death. Therefore, nanoparticles (NPs) prepared with chitosan possess a positive surface charge and mucoadhesive properties that can adhere to microbial mucus membranes and release their drug load in a constant release manner. As the success in therapeutics depends on the targeted delivery of drugs, chitosan nanomaterial, which displays low toxicity, can be safely used for eradicating a biofilm through attenuating the quorum sensing (QS). Since the anti-biofilm potential of chitosan and its nano-derivatives are reported for various microorganisms, these can be used as attractive tools for combating chronic infections and for the preparation of functionalized nanomaterials for different medical devices, such as orthodontic appliances. This mini-review focuses on the mechanism of the downregulation of quorum sensing using functionalized chitosan nanomaterials and the future prospects of its applications.https://www.mdpi.com/2073-4360/13/15/2533antibiofilmchitosannanomaterialquorum quenchingquorum sensing
collection DOAJ
language English
format Article
sources DOAJ
author Moupriya Nag
Dibyajit Lahiri
Dipro Mukherjee
Ritwik Banerjee
Sayantani Garai
Tanmay Sarkar
Sujay Ghosh
Ankita Dey
Sougata Ghosh
Smaranika Pattnaik
Hisham Atan Edinur
Zulhisyam Abdul Kari
Siddhartha Pati
Rina Rani Ray
spellingShingle Moupriya Nag
Dibyajit Lahiri
Dipro Mukherjee
Ritwik Banerjee
Sayantani Garai
Tanmay Sarkar
Sujay Ghosh
Ankita Dey
Sougata Ghosh
Smaranika Pattnaik
Hisham Atan Edinur
Zulhisyam Abdul Kari
Siddhartha Pati
Rina Rani Ray
Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing
Polymers
antibiofilm
chitosan
nanomaterial
quorum quenching
quorum sensing
author_facet Moupriya Nag
Dibyajit Lahiri
Dipro Mukherjee
Ritwik Banerjee
Sayantani Garai
Tanmay Sarkar
Sujay Ghosh
Ankita Dey
Sougata Ghosh
Smaranika Pattnaik
Hisham Atan Edinur
Zulhisyam Abdul Kari
Siddhartha Pati
Rina Rani Ray
author_sort Moupriya Nag
title Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing
title_short Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing
title_full Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing
title_fullStr Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing
title_full_unstemmed Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing
title_sort functionalized chitosan nanomaterials: a jammer for quorum sensing
publisher MDPI AG
series Polymers
issn 2073-4360
publishDate 2021-07-01
description The biggest challenge in the present-day healthcare scenario is the rapid emergence and spread of antimicrobial resistance due to the rampant use of antibiotics in daily therapeutics. Such drug resistance is associated with the enhancement of microbial virulence and the acquisition of the ability to evade the host’s immune response under the shelter of a biofilm. Quorum sensing (QS) is the mechanism by which the microbial colonies in a biofilm modulate and intercept communication without direct interaction. Hence, the eradication of biofilms through hindering this communication will lead to the successful management of drug resistance and may be a novel target for antimicrobial chemotherapy. Chitosan shows microbicidal activities by acting electrostatically with its positively charged amino groups, which interact with anionic moieties on microbial species, causing enhanced membrane permeability and eventual cell death. Therefore, nanoparticles (NPs) prepared with chitosan possess a positive surface charge and mucoadhesive properties that can adhere to microbial mucus membranes and release their drug load in a constant release manner. As the success in therapeutics depends on the targeted delivery of drugs, chitosan nanomaterial, which displays low toxicity, can be safely used for eradicating a biofilm through attenuating the quorum sensing (QS). Since the anti-biofilm potential of chitosan and its nano-derivatives are reported for various microorganisms, these can be used as attractive tools for combating chronic infections and for the preparation of functionalized nanomaterials for different medical devices, such as orthodontic appliances. This mini-review focuses on the mechanism of the downregulation of quorum sensing using functionalized chitosan nanomaterials and the future prospects of its applications.
topic antibiofilm
chitosan
nanomaterial
quorum quenching
quorum sensing
url https://www.mdpi.com/2073-4360/13/15/2533
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