Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia

Brain ischemia induces neuronal loss which is caused in part by excitotoxicity and free radical formation. Here, we report that mangiferin and morin, two antioxidant polyphenols, are neuroprotective in both in vitro and in vivo models of ischemia. Cell death caused by glutamate in neuronal cultures...

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Bibliographic Details
Main Authors: Miroslav Gottlieb, Rocío Leal-Campanario, María Rosario Campos-Esparza, María Victoria Sánchez-Gómez, Elena Alberdi, Amaia Arranz, José María Delgado-García, Agnès Gruart, Carlos Matute
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000751