Priming of the cGAS-STING-TBK1 Pathway Enhances LPS-Induced Release of Type I Interferons

Priming of the cGAS-STING-TBK1 Pathway Enhances LPS-Induced Release of Type I Interferons

Cytoplasmic nucleic acids sensing through cGAS-STING-TBK1 pathway is crucial for the production of antiviral interferons (IFNs). IFN production can also be induced by lipopolysaccharide (LPS) stimulation through Toll-like receptor 4 (TLR4) in appropriate conditions. Of note, both IFN production and...

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Bibliographic Details
Main Authors: Alessandra Tesser, Giulia Maria Piperno, Alessia Pin, Elisa Piscianz, Valentina Boz, Federica Benvenuti, Alberto Tommasini
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
Type I interferons
Toll-like receptor 4
DNase2-deficiency
interferonopathy
Systemic Lupus Erythematosus
Online Access:https://www.mdpi.com/2073-4409/10/4/785

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