Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses

Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses

Mutations in the fused in Sarcoma (FUS) gene induce cytoplasmic FUS aggregations, contributing to the neurodegenerative disease amyotrophic lateral sclerosis (ALS) in certain cases. While FUS is mainly a nuclear protein involved in transcriptional processes with limited cytoplasmic functions, it sho...

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Bibliographic Details
Main Authors: Dhruva Deshpande, Julia Higelin, Michael Schoen, Thomas Vomhof, Tobias M. Boeckers, Maria Demestre, Jens Michaelis
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
FUS
ALS
hiPSCs
motoneuron synapses
super-resolution microscopy
SMLM
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00256/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00256/full

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