MUC1 regulates expression of multiple microRNAs involved in pancreatic tumor progression, including the miR-200c/141 cluster.

MUC1 regulates expression of multiple microRNAs involved in pancreatic tumor progression, including the miR-200c/141 cluster.

MUC1 is a transmembrane glycoprotein that modulates transcription via its cytoplasmic domain. We evaluated the capacity of MUC1 to regulate the global transcription of microRNAs in pancreatic cancer cells expressing MUC1. Results indicated that MUC1 regulated expression of at least 103 microRNAs. We...

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Bibliographic Details
Main Authors: Ashley M Mohr, Jennifer M Bailey, Michelle E Lewallen, Xiang Liu, Prakash Radhakrishnan, Fang Yu, William Tapprich, Michael A Hollingsworth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3797065?pdf=render

Internet

http://europepmc.org/articles/PMC3797065?pdf=render

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