Seroepidemiology of celiac disease among blood donor in Golestan province
Background&Objective: Celiac is a digestive disease. In this disease, small bowel is damaged and the absorption of nutrients are adversely affected. These patients do not absorb gluten. There is probably a correlation between esophagus cancer and celiac. The aim of this research was to study the...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | fas |
Published: |
Golestan University of Medical Sciences
2006-10-01
|
Series: | مجله دانشگاه علوم پزشکی گرگان |
Subjects: | |
Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-75&slc_lang=en&sid=1 |
id |
doaj-fd570ccb8cd54fa998152383c617e02d |
---|---|
record_format |
Article |
spelling |
doaj-fd570ccb8cd54fa998152383c617e02d2020-11-25T01:06:41ZfasGolestan University of Medical Sciences مجله دانشگاه علوم پزشکی گرگان1562-47652008-40802006-10-01834447Seroepidemiology of celiac disease among blood donor in Golestan provinceJoshaghani HR0Semnani Sh1Mirrezaee A2Abdolahi N3Besharat S4Behnampour N5Dehbashi Gh6Roshandel Gh7 Background&Objective: Celiac is a digestive disease. In this disease, small bowel is damaged and the absorption of nutrients are adversely affected. These patients do not absorb gluten. There is probably a correlation between esophagus cancer and celiac. The aim of this research was to study the seroepidemiology celiac disease in this area with high prevalency of esophagus cancer. Materials&Methods: This research was a descriptive study, which was performed on blood donors in Golestan province during the year 2005-06. blood samples were taken from 2547 subjects. tTG-IgA determination were carried out using ElISA technique, the titre<4U/ml, 4-10U/ml and >10Um/l were considered to be as negative, weakly positive and positive respectively. EMA antibody assessment were carried out on all sample population with more than 4U/ml, using IFA method. Results: 28 subjects (1.1%) had tTG-Ab positive test, out of this number 18 subjects (0.7%) were weakly positive and 10 persons (0.4%) were considered to be positive. EMA test were positive in 70% of subjects with tTG positive results. There was not any significant meaning between positive tTG test and ethnicity from weakly positive tTG, 15 subjects (83.3%) and 3 subjects (16.7%) were male and female respectively. The entire tTG positive were male subjects. Conclusion: In regard to high prevalency of esophagus cancer in the region and the relation of celiac disease with above cancer, it seems necessary to look more seriously at the celiac disease.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-75&slc_lang=en&sid=1Antiendomysial antibodiesTissue transglutaminaseCeliacGolestanEsophagus cancer |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Joshaghani HR Semnani Sh Mirrezaee A Abdolahi N Besharat S Behnampour N Dehbashi Gh Roshandel Gh |
spellingShingle |
Joshaghani HR Semnani Sh Mirrezaee A Abdolahi N Besharat S Behnampour N Dehbashi Gh Roshandel Gh Seroepidemiology of celiac disease among blood donor in Golestan province مجله دانشگاه علوم پزشکی گرگان Antiendomysial antibodies Tissue transglutaminase Celiac Golestan Esophagus cancer |
author_facet |
Joshaghani HR Semnani Sh Mirrezaee A Abdolahi N Besharat S Behnampour N Dehbashi Gh Roshandel Gh |
author_sort |
Joshaghani HR |
title |
Seroepidemiology of celiac disease among blood donor in Golestan province |
title_short |
Seroepidemiology of celiac disease among blood donor in Golestan province |
title_full |
Seroepidemiology of celiac disease among blood donor in Golestan province |
title_fullStr |
Seroepidemiology of celiac disease among blood donor in Golestan province |
title_full_unstemmed |
Seroepidemiology of celiac disease among blood donor in Golestan province |
title_sort |
seroepidemiology of celiac disease among blood donor in golestan province |
publisher |
Golestan University of Medical Sciences |
series |
مجله دانشگاه علوم پزشکی گرگان |
issn |
1562-4765 2008-4080 |
publishDate |
2006-10-01 |
description |
Background&Objective: Celiac is a digestive disease. In this disease, small bowel is damaged and the absorption of nutrients are adversely affected. These patients do not absorb gluten. There is probably a correlation between esophagus cancer and celiac. The aim of this research was to study the seroepidemiology celiac disease in this area with high prevalency of esophagus cancer. Materials&Methods: This research was a descriptive study, which was performed on blood donors in Golestan province during the year 2005-06. blood samples were taken from 2547 subjects. tTG-IgA determination were carried out using ElISA technique, the titre<4U/ml, 4-10U/ml and >10Um/l were considered to be as negative, weakly positive and positive respectively. EMA antibody assessment were carried out on all sample population with more than 4U/ml, using IFA method. Results: 28 subjects (1.1%) had tTG-Ab positive test, out of this number 18 subjects (0.7%) were weakly positive and 10 persons (0.4%) were considered to be positive. EMA test were positive in 70% of subjects with tTG positive results. There was not any significant meaning between positive tTG test and ethnicity from weakly positive tTG, 15 subjects (83.3%) and 3 subjects (16.7%) were male and female respectively. The entire tTG positive were male subjects. Conclusion: In regard to high prevalency of esophagus cancer in the region and the relation of celiac disease with above cancer, it seems necessary to look more seriously at the celiac disease. |
topic |
Antiendomysial antibodies Tissue transglutaminase Celiac Golestan Esophagus cancer |
url |
http://goums.ac.ir/journal/browse.php?a_code=A-10-1-75&slc_lang=en&sid=1 |
work_keys_str_mv |
AT joshaghanihr seroepidemiologyofceliacdiseaseamongblooddonoringolestanprovince AT semnanish seroepidemiologyofceliacdiseaseamongblooddonoringolestanprovince AT mirrezaeea seroepidemiologyofceliacdiseaseamongblooddonoringolestanprovince AT abdolahin seroepidemiologyofceliacdiseaseamongblooddonoringolestanprovince AT besharats seroepidemiologyofceliacdiseaseamongblooddonoringolestanprovince AT behnampourn seroepidemiologyofceliacdiseaseamongblooddonoringolestanprovince AT dehbashigh seroepidemiologyofceliacdiseaseamongblooddonoringolestanprovince AT roshandelgh seroepidemiologyofceliacdiseaseamongblooddonoringolestanprovince |
_version_ |
1725188778377609216 |