Seroepidemiology of celiac disease among blood donor in Golestan province

Background&Objective: Celiac is a digestive disease. In this disease, small bowel is damaged and the absorption of nutrients are adversely affected. These patients do not absorb gluten. There is probably a correlation between esophagus cancer and celiac. The aim of this research was to study the...

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Main Authors: Joshaghani HR, Semnani Sh, Mirrezaee A, Abdolahi N, Besharat S, Behnampour N, Dehbashi Gh, Roshandel Gh
Format: Article
Language:fas
Published: Golestan University of Medical Sciences 2006-10-01
Series:مجله دانشگاه علوم پزشکی گرگان
Subjects:
Online Access:http://goums.ac.ir/journal/browse.php?a_code=A-10-1-75&slc_lang=en&sid=1
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spelling doaj-fd570ccb8cd54fa998152383c617e02d2020-11-25T01:06:41ZfasGolestan University of Medical Sciences مجله دانشگاه علوم پزشکی گرگان1562-47652008-40802006-10-01834447Seroepidemiology of celiac disease among blood donor in Golestan provinceJoshaghani HR0Semnani Sh1Mirrezaee A2Abdolahi N3Besharat S4Behnampour N5Dehbashi Gh6Roshandel Gh7 Background&Objective: Celiac is a digestive disease. In this disease, small bowel is damaged and the absorption of nutrients are adversely affected. These patients do not absorb gluten. There is probably a correlation between esophagus cancer and celiac. The aim of this research was to study the seroepidemiology celiac disease in this area with high prevalency of esophagus cancer. Materials&Methods: This research was a descriptive study, which was performed on blood donors in Golestan province during the year 2005-06. blood samples were taken from 2547 subjects. tTG-IgA determination were carried out using ElISA technique, the titre<4U/ml, 4-10U/ml and >10Um/l were considered to be as negative, weakly positive and positive respectively. EMA antibody assessment were carried out on all sample population with more than 4U/ml, using IFA method. Results: 28 subjects (1.1%) had tTG-Ab positive test, out of this number 18 subjects (0.7%) were weakly positive and 10 persons (0.4%) were considered to be positive. EMA test were positive in 70% of subjects with tTG positive results. There was not any significant meaning between positive tTG test and ethnicity from weakly positive tTG, 15 subjects (83.3%) and 3 subjects (16.7%) were male and female respectively. The entire tTG positive were male subjects. Conclusion: In regard to high prevalency of esophagus cancer in the region and the relation of celiac disease with above cancer, it seems necessary to look more seriously at the celiac disease.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-75&slc_lang=en&sid=1Antiendomysial antibodiesTissue transglutaminaseCeliacGolestanEsophagus cancer
collection DOAJ
language fas
format Article
sources DOAJ
author Joshaghani HR
Semnani Sh
Mirrezaee A
Abdolahi N
Besharat S
Behnampour N
Dehbashi Gh
Roshandel Gh
spellingShingle Joshaghani HR
Semnani Sh
Mirrezaee A
Abdolahi N
Besharat S
Behnampour N
Dehbashi Gh
Roshandel Gh
Seroepidemiology of celiac disease among blood donor in Golestan province
مجله دانشگاه علوم پزشکی گرگان
Antiendomysial antibodies
Tissue transglutaminase
Celiac
Golestan
Esophagus cancer
author_facet Joshaghani HR
Semnani Sh
Mirrezaee A
Abdolahi N
Besharat S
Behnampour N
Dehbashi Gh
Roshandel Gh
author_sort Joshaghani HR
title Seroepidemiology of celiac disease among blood donor in Golestan province
title_short Seroepidemiology of celiac disease among blood donor in Golestan province
title_full Seroepidemiology of celiac disease among blood donor in Golestan province
title_fullStr Seroepidemiology of celiac disease among blood donor in Golestan province
title_full_unstemmed Seroepidemiology of celiac disease among blood donor in Golestan province
title_sort seroepidemiology of celiac disease among blood donor in golestan province
publisher Golestan University of Medical Sciences
series مجله دانشگاه علوم پزشکی گرگان
issn 1562-4765
2008-4080
publishDate 2006-10-01
description Background&Objective: Celiac is a digestive disease. In this disease, small bowel is damaged and the absorption of nutrients are adversely affected. These patients do not absorb gluten. There is probably a correlation between esophagus cancer and celiac. The aim of this research was to study the seroepidemiology celiac disease in this area with high prevalency of esophagus cancer. Materials&Methods: This research was a descriptive study, which was performed on blood donors in Golestan province during the year 2005-06. blood samples were taken from 2547 subjects. tTG-IgA determination were carried out using ElISA technique, the titre<4U/ml, 4-10U/ml and >10Um/l were considered to be as negative, weakly positive and positive respectively. EMA antibody assessment were carried out on all sample population with more than 4U/ml, using IFA method. Results: 28 subjects (1.1%) had tTG-Ab positive test, out of this number 18 subjects (0.7%) were weakly positive and 10 persons (0.4%) were considered to be positive. EMA test were positive in 70% of subjects with tTG positive results. There was not any significant meaning between positive tTG test and ethnicity from weakly positive tTG, 15 subjects (83.3%) and 3 subjects (16.7%) were male and female respectively. The entire tTG positive were male subjects. Conclusion: In regard to high prevalency of esophagus cancer in the region and the relation of celiac disease with above cancer, it seems necessary to look more seriously at the celiac disease.
topic Antiendomysial antibodies
Tissue transglutaminase
Celiac
Golestan
Esophagus cancer
url http://goums.ac.ir/journal/browse.php?a_code=A-10-1-75&slc_lang=en&sid=1
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