Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases

Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases

Lack of B0AT1 (SLC6A19) partially protects mice against the onset of non-alcoholic steatohepatitis (NASH). To achieve a similar outcome through pharmacological treatment, we improved previously identified inhibitors of B0AT1 by medicinal chemistry and identified second generation inhibitors by high...

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Bibliographic Details
Main Authors: Aditya Yadav, Nishank Shah, Praveen Kumar Tiwari, Kiran Javed, Qi Cheng, Indrapal Singh Aidhen, Stefan Bröer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
phenylketonuria
steatohepatitis
non-alcoholic steatohepatitis
solute carrier
high throughput screening
HTS
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00140/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00140/full

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