PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects

PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects

Abstract Background Inflammation is associated with major depressive disorder (MDD). Translocator protein 18 kDa (TSPO), a putative biomarker of neuroinflammation, is quantified using positron emission tomography (PET) and 11C-PBR28, a TSPO tracer. We sought to (1) investigate TSPO binding in MDD su...

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Bibliographic Details
Main Authors: Erica M. Richards, Paolo Zanotti-Fregonara, Masahiro Fujita, Laura Newman, Cristan Farmer, Elizabeth D. Ballard, Rodrigo Machado-Vieira, Peixiong Yuan, Mark J. Niciu, Chul Hyoung Lyoo, Ioline D. Henter, Giacomo Salvadore, Wayne C. Drevets, Hartmuth Kolb, Robert B. Innis, Carlos A. Zarate Jr
Format: Article
Language:English
Published: SpringerOpen 2018-07-01
Series:EJNMMI Research
Subjects:
Inflammation
Major depressive disorder
Biomarkers
Peripheral benzodiazepine receptor
Positron emission tomography
Online Access:http://link.springer.com/article/10.1186/s13550-018-0401-9

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http://link.springer.com/article/10.1186/s13550-018-0401-9

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