MicroRNA-298 Reverses Multidrug Resistance to Antiepileptic Drugs by Suppressing MDR1/P-gp Expression in vitro

MicroRNA-298 Reverses Multidrug Resistance to Antiepileptic Drugs by Suppressing MDR1/P-gp Expression in vitro

P-glycoprotein (P-gp), a critical multidrug transporter, recognizes and transports various antiepileptic drugs (AEDs) through the blood-brain barrier (BBB). This may decrease the concentrations of AEDs in brain tissues and cause multidrug resistance (MDR) in patients with refractory epilepsy. Compel...

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Bibliographic Details
Main Authors: Yangmei Xie, Yiye Shao, Xiaolin Deng, Ming Wang, Yinghui Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
microRNA-298
P-glycoprotein
antiepileptic drugs
multidrug resistance
refractory epilepsy
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00602/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00602/full

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