Molecular genetic aspects of intrahepatic cholangiocarcinoma: literature review

• Main Authors: B. N. Gurmikov, Yu. A. Kovalenko, V. A. Vishnevsky, A. V. Chzhao
• Format: Article
• Language: Russian
• Published: ABV-press 2019-04-01
• Series: Uspehi Molekulârnoj Onkologii
• Subjects: intrahepatic cholangiocarcinoma; molecular genetic aspects; targeted therapy; staging
• Online Access: https://umo.abvpress.ru/jour/article/view/204

The modern concept of therapy for intrahepatic cholangiocarcinoma including surgical treatment, must take into account the achievements of molecular biology and modern staging principles. A detailed understanding of the molecular genetic (genetic and epigenetic) disorders underlying the pathogenesis of cholangiocarcinoma is important, which will improve the results of surgical treatment and expand the possibilities of personalized (targeted) therapy. Based on new data on cholangiocarcinogenesis, molecular profiling of bile duct tumors may be most appropriate for the selection of treatment in cases refractory to standard therapy. Current potential target therapy targets include endothelial growth factor receptors, fibroblast growth factor, MET tyrosine kinase, PI3K/Akt/mTOR signaling pathway and isocitrate dehydrogenase mutation. The review considers the molecular-genetic aspects underlying the pathogenesis and modern principles of staging intrahepatic cholangiocarcinoma.