Seoul Virus and Hantavirus Disease, Shenyang, People’s Republic of China
An outbreak of hemorrhagic fever with renal syndrome (HFRS) occurred among students in Shenyang Pharmaceutical University in 2006. We conducted a study to characterize etiologic agents of the outbreaks and clarify the origin of hantaviruses causing infections in humans and laboratory animals. Immuno...
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Centers for Disease Control and Prevention
2009-02-01
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doaj-feeeda1591824783a062555592c7fc902020-11-25T02:46:34ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592009-02-0115220020610.3201/eid1502.080291Seoul Virus and Hantavirus Disease, Shenyang, People’s Republic of ChinaYong-Zhen ZhangXue DongXin LiChao MaHai-Ping XiongGuang-Jie YanNa GaoDong-Mei JiangMing-Hui LiLu-Ping LiYang ZouAlexander PlyusninAn outbreak of hemorrhagic fever with renal syndrome (HFRS) occurred among students in Shenyang Pharmaceutical University in 2006. We conducted a study to characterize etiologic agents of the outbreaks and clarify the origin of hantaviruses causing infections in humans and laboratory animals. Immunoglobulin (Ig) M or IgG antibodies against Seoul virus (SEOV) were detected in the serum samples of all 8 patients. IgG antibodies against hantavirus were also identified in laboratory rats, which were used by these students for their scientific research. Phylogenetic analysis showed that partial small segment sequences recovered from humans, laboratory rats, and local wild rats belonged to SEOV. Hantavirus sequences recovered from humans and laboratory rats clustered within 1 of 3 lineages of SEOV circulating among local wild rats in Shenyang. These results suggest that the HFRS outbreak in Shenyang was caused by SEOV that was circulating among local wild rats and had also infected the laboratory rats.https://wwwnc.cdc.gov/eid/article/15/2/08-0291_articleHFRS outbreakhantavirusSeoul viruslaboratory ratswild Norway ratsChina |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong-Zhen Zhang Xue Dong Xin Li Chao Ma Hai-Ping Xiong Guang-Jie Yan Na Gao Dong-Mei Jiang Ming-Hui Li Lu-Ping Li Yang Zou Alexander Plyusnin |
spellingShingle |
Yong-Zhen Zhang Xue Dong Xin Li Chao Ma Hai-Ping Xiong Guang-Jie Yan Na Gao Dong-Mei Jiang Ming-Hui Li Lu-Ping Li Yang Zou Alexander Plyusnin Seoul Virus and Hantavirus Disease, Shenyang, People’s Republic of China Emerging Infectious Diseases HFRS outbreak hantavirus Seoul virus laboratory rats wild Norway rats China |
author_facet |
Yong-Zhen Zhang Xue Dong Xin Li Chao Ma Hai-Ping Xiong Guang-Jie Yan Na Gao Dong-Mei Jiang Ming-Hui Li Lu-Ping Li Yang Zou Alexander Plyusnin |
author_sort |
Yong-Zhen Zhang |
title |
Seoul Virus and Hantavirus Disease, Shenyang, People’s Republic of China |
title_short |
Seoul Virus and Hantavirus Disease, Shenyang, People’s Republic of China |
title_full |
Seoul Virus and Hantavirus Disease, Shenyang, People’s Republic of China |
title_fullStr |
Seoul Virus and Hantavirus Disease, Shenyang, People’s Republic of China |
title_full_unstemmed |
Seoul Virus and Hantavirus Disease, Shenyang, People’s Republic of China |
title_sort |
seoul virus and hantavirus disease, shenyang, people’s republic of china |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2009-02-01 |
description |
An outbreak of hemorrhagic fever with renal syndrome (HFRS) occurred among students in Shenyang Pharmaceutical University in 2006. We conducted a study to characterize etiologic agents of the outbreaks and clarify the origin of hantaviruses causing infections in humans and laboratory animals. Immunoglobulin (Ig) M or IgG antibodies against Seoul virus (SEOV) were detected in the serum samples of all 8 patients. IgG antibodies against hantavirus were also identified in laboratory rats, which were used by these students for their scientific research. Phylogenetic analysis showed that partial small segment sequences recovered from humans, laboratory rats, and local wild rats belonged to SEOV. Hantavirus sequences recovered from humans and laboratory rats clustered within 1 of 3 lineages of SEOV circulating among local wild rats in Shenyang. These results suggest that the HFRS outbreak in Shenyang was caused by SEOV that was circulating among local wild rats and had also infected the laboratory rats. |
topic |
HFRS outbreak hantavirus Seoul virus laboratory rats wild Norway rats China |
url |
https://wwwnc.cdc.gov/eid/article/15/2/08-0291_article |
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