Assessment of the impact of PTGS1, PTGS2 and CYP2C9 polymorphisms on pain, effectiveness and safety of NSAID therapies

Assessment of the impact of PTGS1, PTGS2 and CYP2C9 polymorphisms on pain, effectiveness and safety of NSAID therapies

Cyclooxygenase 1 and 2 (COX-1, COX-2) are enzymes that catalyze the first reaction in the arachidonic acid pathway. COXs are the therapeutic target for non-steroidal anti-inflammatory drugs. Inhibition of COX enzymatic activity has an analgesic, anti-inflammatory and sometimes antiplatelet effect. S...

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Bibliographic Details
Main Authors: Miriam Dawidowicz, Agnieszka Kula, Paweł Świętochowski, Zofia Ostrowska
Format: Article
Language:English
Published: Index Copernicus International S.A. 2020-11-01
Series:Postępy Higieny i Medycyny Doświadczalnej
Subjects:
SNPs
COX-1
COX-2
COX-3
NSAIDs
CYP2C9
Online Access:http://phmd.pl/gicid/01.3001.0014.5497

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