Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans
Background Beta-2 adrenergic receptors (β 2 ARs) are located throughout the body including airway and alveolar cells. The β 2 ARs regulate lung fluid clearance through a variety of mechanisms including ion transport on alveolar cells and relaxation of the pulmonary lymphatics. We examined the effect...
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doaj-ff7a9a6615f54af9b17f19479594d90f2020-11-25T03:43:38ZengSAGE PublishingClinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine1179-54842016-01-011010.4137/CCRPM.S30251Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy HumansNatalie E. Taylor0Sarah E. Baker1Thomas P. Olson2Sophie Lalande3Bruce D. Johnson4Eric M. Snyder5School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.Research Fellow, Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA.Consultant, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.Department of Kinesiology, University of Toledo, OH, USA.Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.School of Kinesiology, University of Minnesota, Minneapolis, MN, USA.Background Beta-2 adrenergic receptors (β 2 ARs) are located throughout the body including airway and alveolar cells. The β 2 ARs regulate lung fluid clearance through a variety of mechanisms including ion transport on alveolar cells and relaxation of the pulmonary lymphatics. We examined the effect of an inhaled β 2 -agonist (albuterol) on alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume ( V C ) in healthy humans. Methods We assessed the diffusing capacity of the lungs for carbon monoxide (DLCO) and nitric oxide (DLNO) at baseline, 30 minutes, and 60 minutes following nebulized albuterol (2.5 mg, diluted in 3 mL normal saline) in 45 healthy subjects. Seventeen subjects repeated these measures following nebulized normal saline (age = 27 ± 9 years, height = 165 ± 21 cm, weight = 68 ± 12 kg, BMI = 26 ± 9 kg/m 2 ). Cardiac output (Q), heart rate, systemic vascular resistance (SVR), blood pressure, oxygen saturation, forced expiratory volume at one-second (FEV 1 ), and forced expiratory flow at 50% of forced vital capacity (FEF 50 ) were assessed at baseline, 30 minutes, and 60 minutes following the administration of albuterol or saline. Results Albuterol resulted in a decrease in SVR, and an increase in Q, FEV 1 , and FEF 50 compared to saline controls. Albuterol also resulted in a decrease in V C at 60 minutes post albuterol. Both albuterol and normal saline resulted in no change in DLCO or DM when assessed alone, but a significant increase was observed in DM when accounting for changes in V C . Conclusion These data suggest that nebulized albuterol improves pulmonary function in healthy humans, while nebulization of both albuterol and saline results in an increase in DM/ V C .https://doi.org/10.4137/CCRPM.S30251 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Natalie E. Taylor Sarah E. Baker Thomas P. Olson Sophie Lalande Bruce D. Johnson Eric M. Snyder |
spellingShingle |
Natalie E. Taylor Sarah E. Baker Thomas P. Olson Sophie Lalande Bruce D. Johnson Eric M. Snyder Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine |
author_facet |
Natalie E. Taylor Sarah E. Baker Thomas P. Olson Sophie Lalande Bruce D. Johnson Eric M. Snyder |
author_sort |
Natalie E. Taylor |
title |
Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans |
title_short |
Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans |
title_full |
Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans |
title_fullStr |
Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans |
title_full_unstemmed |
Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans |
title_sort |
albuterol improves alveolar-capillary membrane conductance in healthy humans |
publisher |
SAGE Publishing |
series |
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine |
issn |
1179-5484 |
publishDate |
2016-01-01 |
description |
Background Beta-2 adrenergic receptors (β 2 ARs) are located throughout the body including airway and alveolar cells. The β 2 ARs regulate lung fluid clearance through a variety of mechanisms including ion transport on alveolar cells and relaxation of the pulmonary lymphatics. We examined the effect of an inhaled β 2 -agonist (albuterol) on alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume ( V C ) in healthy humans. Methods We assessed the diffusing capacity of the lungs for carbon monoxide (DLCO) and nitric oxide (DLNO) at baseline, 30 minutes, and 60 minutes following nebulized albuterol (2.5 mg, diluted in 3 mL normal saline) in 45 healthy subjects. Seventeen subjects repeated these measures following nebulized normal saline (age = 27 ± 9 years, height = 165 ± 21 cm, weight = 68 ± 12 kg, BMI = 26 ± 9 kg/m 2 ). Cardiac output (Q), heart rate, systemic vascular resistance (SVR), blood pressure, oxygen saturation, forced expiratory volume at one-second (FEV 1 ), and forced expiratory flow at 50% of forced vital capacity (FEF 50 ) were assessed at baseline, 30 minutes, and 60 minutes following the administration of albuterol or saline. Results Albuterol resulted in a decrease in SVR, and an increase in Q, FEV 1 , and FEF 50 compared to saline controls. Albuterol also resulted in a decrease in V C at 60 minutes post albuterol. Both albuterol and normal saline resulted in no change in DLCO or DM when assessed alone, but a significant increase was observed in DM when accounting for changes in V C . Conclusion These data suggest that nebulized albuterol improves pulmonary function in healthy humans, while nebulization of both albuterol and saline results in an increase in DM/ V C . |
url |
https://doi.org/10.4137/CCRPM.S30251 |
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