Celiac disease in Iran: a systematic review and meta-analysis

• Main Authors: Roghayeh Mohammadibakhsh, Rahim Sohrabi, Morteza Salemi, Masood Taheri Mirghaed, Masoud Behzadifar
• Format: Article
• Language: English
• Published: Electronic Physician 2017-03-01
• Series: Electronic Physician
• Subjects: Prevalence; Meta-analysis; Celiac disease; Iran
• Online Access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407219/

Introduction: Celiac disease (CD) is a chronic autoimmune-mediated disorder with both intestinal and systemic manifestations. The aim of this study was to determine the prevalence of celiac disease in Iran. Methods: We conducted a systematic search on Embase, Pub Med, Web of Science, Google Scholar, MagIran, Scientific Information database (SID) and Iranmedex from 2003 through to November 2015. The Der-Simonian/ Laird’s (DL), with a 95% confidence interval employed to estimate the overall pooled prevalence. Heterogeneity was investigated by using subgroup analysis based on sample size and time of study. Results: Sixty-three studies with 36,833 participants met inclusion criteria for analysis. The overall prevalence of celiac disease in 63 studies that had used serological tests for the diagnosis was observed as 3% (95% CI: 0.03- 0.03) and the overall prevalence of celiac disease in studies that had used biopsy method for diagnosis was observed as 2% (95% CI: 0.01- 0.02). Conclusion: The prevalence of celiac disease in Iran was similar or even higher than world-wide reported