Synthesis of MCR-1 Inhibitors to Overcome Antibacterial Resistance
This thesis describes the synthesis of a series of pyrazole and isoflavone analogues in order to find drug-like molecules which can act as an inhibitor of MCR-1 (mobilised colistin resistance). This enzyme causes resistance to the last resort antibiotic - colistin (polymyxin E) which has recently be...
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| Format: | Others |
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Auckland University of Technology,
2019-06-10T02:55:47Z.
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| Online Access: | Get fulltext |