Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

The retinoblastoma tumor suppressor (pRb) protein associates with chromatin and regulates gene expression. Numerous studies have identified Rb-dependent RNA signatures, but the proteomic effects of Rb loss are largely unexplored. We acutely ablated Rb in adult mice and conducted a quantitative analy...

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Main Authors: Nicolay, Brandon N. (Author), Danielian, Paul S. (Contributor), Kottakis, Filippos (Author), Lapek, John D. (Author), Sanidas, Ioannis (Author), Miles, Wayne O. (Author), Dehnad, Mantre (Author), Gierut, Jessica J. (Author), Manning, Amity L. (Author), Morris, Robert (Author), Haigis, Kevin (Author), Bardeesy, Nabeel (Author), Haas, Wilhelm (Author), Dyson, Nicholas J. (Author), Lees, Jacquelineb (Author), Tschop, Katrin (Author), Lees, Jacqueline (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2016-04-04T16:14:15Z.
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