Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA demethylation. Despite the abundance of 5hmC and Tet proteins in the brain, little is known about the functions of the neuronal Tet...

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Main Authors: Rudenko, Andrii (Contributor), Dawlaty, Meelad M (Author), Seo, Jinsoo (Contributor), Cheng, Albert W (Author), Meng, Jia (Contributor), Le, Thuc (Author), Faull, Kym F (Author), Jaenisch, Rudolf (Contributor), Tsai, Li-Huei (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-05-16T13:55:09Z.
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