CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

Th17 cells play a critical role in host defense against extracellular pathogens and tissue homeostasis, but can induce autoimmunity. The mechanisms implicated in balancing 'pathogenic' and 'non-pathogenic' Th17 cell states remain largely unknown. We used single-cell RNA-seq to id...

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Main Authors: Wang, Chao (Author), Yosef, Nir (Author), Gaublomme, Jellert (Author), Wu, Chuan (Author), Lee, Youjin (Author), Clish, Clary B (Author), Kaminski, Jim (Author), Xiao, Sheng (Author), Zu Horste, Gerd Meyer (Author), Pawlak, Mathias (Author), Kishi, Yasuhiro (Author), Joller, Nicole (Author), Karwacz, Katarzyna (Author), Zhu, Chen (Author), Ordovas-Montanes, Maria (Author), Madi, Asaf (Author), Wortman, Ivo (Author), Miyazaki, Toru (Author), Sobel, Raymond A (Author), Park, Hongkun (Author), Regev, Aviv (Contributor), Kuchroo, Vijay K (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-12-09T15:42:32Z.
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