Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

Super-enhancers and stretch enhancers (SEs) drive expression of genes that play prominent roles in normal and disease cells, but the functional importance of these clustered enhancer elements is poorly understood, so it is not clear why genes key to cell identity have evolved regulation by such elem...

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Bibliographic Details
Main Authors: Hnisz, Denes (Author), Schuijers, Jurian (Author), Lin, Charles Y (Author), Abraham, Brian J (Author), Lee, Tong Ihn (Author), Bradner, James E (Author), Weintraub, Abraham Selby (Contributor), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-01-12T20:32:06Z.
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