Circulating CXCR5[superscript +]CXCR3[superscript +]PD-1[superscript lo] Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

Circulating CXCR5[superscript +]CXCR3[superscript +]PD-1[superscript lo] Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

HIV-1-specific broadly neutralizing antibodies (bnAbs) typically develop in individuals with continuous high-level viral replication and increased immune activation, conditions that cannot be reproduced during prophylactic immunization. Understanding mechanisms supporting bnAb development in the abs...

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Main Authors: Martin-Gayo, Enrique (Author), Cronin, Jacqueline (Author), Hickman, Taylor (Author), Ouyang, Zhengyu (Author), Lindqvist, Madelene (Author), Schulze zur Wiesch, Julian (Author), Cubas, Rafael (Author), Porichis, Filippos (Author), van Lunzen, Jan (Author), Haddad, Elias K. (Author), Walker, Bruce D. (Author), Kaufmann, Daniel E. (Author), Lichterfeld, Mathias (Author), Yu, Xu G. (Author), Kolb, Kellie Elizabeth (Contributor), Shalek, Alexander K (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Shalek, Alex K. (Contributor)
Format: Article
Language:English
Published: American Society for Clinical Investigation, 2018-05-01T14:58:53Z.
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