Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation

Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation

Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differen...

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Main Authors: Karwacz, Katarzyna (Author), Miraldi, Emily R (Author), Pokrovskii, Maria (Author), Madi, Asaf (Author), Yosef, Nir (Author), Wortman, Ivo (Author), Chen, Xi (Author), Watters, Aaron (Author), Carriero, Nicholas (Author), Awasthi, Amit (Author), Bonneau, Richard (Author), Littman, Dan (Author), Kuchroo, Vijay K (Author), Regev, Aviv (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-02T20:19:15Z.
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