T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

In the small intestine, a niche of accessory cell types supports the generation of mature epithelial cell types from intestinal stem cells (ISCs). It is unclear, however, if and how immune cells in the niche affect ISC fate or the balance between self-renewal and differentiation. Here, we use single...

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Main Authors: Biton, Moshe (Author), Haber, Adam L. (Author), Rogel, Noga (Author), Burgin, Grace (Author), Beyaz, Semir (Author), Schnell, Alexandra (Author), Ashenberg, Orr (Author), Su, Chien-Wen (Author), Smillie, Christopher (Author), Shekhar, Karthik (Author), Chen, Zuojia (Author), Wu, Chuan (Author), Ordovas-Montanes, Jose Manuel (Author), Alvarez, David (Author), Herbst, Rebecca H. (Author), Zhang, Mei (Author), Tirosh, Itay (Author), Dionne, Danielle (Author), Nguyen, Lan T. (Author), Xifaras, Michael (Author), Shalek, Alexander K (Author), von Andrian, Ulrich H. (Author), Graham, Daniel B. (Author), Rozenblatt-Rosen, Orit (Author), Shi, Hai Ning (Author), Kuchroo, Vijay (Author), Yilmaz, Omer (Author), Regev, Aviv (Author), Xavier, Ramnik Joseph (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics (Contributor)
Format: Article
Language:English
Published: Elsevier Science Ltd., 2020-01-23T19:01:29Z.
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