Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Neoantigens, which are derived from tumour-specific protein-coding mutations, are exempt from central tolerance, can generate robust immune responses1,2 and can function as bona fide antigens that facilitate tumour rejection3. Here we demonstrate that a strategy that uses multi-epitope, personalized...

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Main Authors: Keskin, Derin B. (Author), Anandappa, Annabelle J. (Author), Sun, Jing (Author), Tirosh, Itay (Author), Mathewson, Nathan D. (Author), Li, Shuqiang (Author), Oliveira, Giacomo (Author), Giobbie-Hurder, Anita (Author), Felt, Kristen (Author), Gjini, Evisa (Author), Shukla, Sachet A. (Author), Hu, Zhuting (Author), Li, Letitia (Author), Le, Phuong M. (Author), Allesøe, Rosa L. (Author), Richman, Alyssa R. (Author), Kowalczyk, Monika S. (Author), Abdelrahman, Sara (Author), Geduldig, Jack E. (Author), Charbonneau, Sarah (Author), Pelton, Kristine (Author), Iorgulescu, J. Bryan (Author), Elagina, Liudmila (Author), Zhang, Wandi (Author), Olive, Oriol (Author), McCluskey, Christine (Author), Olsen, Lars R. (Author), Stevens, Jonathan (Author), Lane, William J. (Author), Salazar, Andres M. (Author), Daley, Heather (Author), Wen, Patrick Y. (Author), Chiocca, E. Antonio (Author), Harden, Maegan (Author), Lennon, Niall (Author), Gabriel, Stacey (Author), Getz, Gad Asher (Author), Lander, Eric Steven (Author), Regev, Aviv (Author), Ritz, Jerome (Author), Neuberg, Donna (Author), Rodig, Scott J. (Author), Ligon, Keith L. (Author), Suvà, Mario L. (Author), Wucherpfennig, Kai W. (Author), Hacohen, Nir (Author), Fritsch, Edward F. (Author), Livak, Kenneth J. (Author), Ott, Patrick A. (Author), Wu, Catherine J. (Author), Reardon, David A. (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-05-21T21:18:10Z.
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