A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2
A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancem...
Main Authors: | Snead, David R. (Author), Gopalsamuthiram, Vijayagopal (Author), Williams, Corshai (Author), Noble, Jeffrey (Author), Jamison, Timothy F. (Author), Gupton, B. Frank (Author) |
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Format: | Article |
Language: | English |
Published: |
Georg Thieme Verlag KG,
2022-03-23T13:51:22Z.
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Subjects: | |
Online Access: | Get fulltext |
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