Lipid-like materials for low-dose, in vivo gene silencing

Lipid-like materials for low-dose, in vivo gene silencing

Significant effort has been applied to discover and develop vehicles which can guide small interfering RNAs (siRNA) through the many barriers guarding the interior of target cells. While studies have demonstrated the potential of gene silencing in vivo, improvements in delivery efficacy are required...

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Main Authors: Mahon, Kerry P. (Contributor), Levins, Christopher G. (Contributor), Whitehead, Kathryn Ann (Contributor), Querbes, William (Author), Dorkin, Joseph Robert (Author), Qin, June (Author), Cantley, William (Author), Qin, Liu Liang (Author), Racie, Timothy (Author), Frank-Kamenetsky, Maria (Author), Yip, Ka (Contributor), Alvarez, Rene (Author), Sah, Dinah W. Y. (Author), de Fougerolles, Antonin (Author), Fitzgerald, Kevin (Author), Kotelianski, Victor E. (Author), Akinc, Akin (Author), Love, Kevin T (Author), Langer, Robert S (Author), Anderson, Daniel Griffith (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Langer, Robert (Contributor), Love, Kevin T. (Contributor), Anderson, Daniel G. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2011-03-01T16:32:48Z.
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