Splice site strength-dependent activity and genetic buffering by poly-G runs

Splice site strength-dependent activity and genetic buffering by poly-G runs

Pre-mRNA splicing is regulated through the combinatorial activity of RNA motifs, including splice sites and splicing regulatory elements. Here we show that the activity of the G-run (polyguanine sequence) class of splicing enhancer elements is approx4-fold higher when adjacent to intermediate streng...

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Bibliographic Details
Main Authors: Xiao, Xinshu (Contributor), Wang, Zefeng (Contributor), Jang, Minyoung (Contributor), Nutiu, Razvan (Contributor), Wang, Eric T (Author), Burge, Christopher B (Author)
Other Authors: Whitaker College of Health Sciences and Technology (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Burge, Christopher B. (Contributor), Wang, Eric T. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2011-10-25T13:49:55Z.
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