Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

Cellular immune control of HIV is mediated, in part, by induction of single amino acid mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we sought to determine if higher order constraints on viral evolution exist, because some coordinately linked combinations o...

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Main Authors: Pereyra, Florencia (Author), Miura, Toshiyuki (Author), Allen, Todd M. (Author), Altfeld, Marcus (Author), Carrington, Mary (Author), Walker, Bruce D. (Author), Dahirel, Vincent (Contributor), Shekhar, Karthik (Contributor), Artyomov, Mikita (Contributor), Talsania, Shiv (Contributor), Irvine, Darrell J. (Contributor), Chakraborty, Arup K. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences (PNAS), 2012-02-01T22:14:44Z.
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