A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 Acute Lymphocytic Leukemia cells

A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 Acute Lymphocytic Leukemia cells

MLL-AF4 Acute Lymphocytic Leukemia has a poor prognosis, and the mechanisms by which these leukemias develop are not understood despite intensive research based on well-known concepts and methods. MicroRNAs (miRNAs) are a new class of small noncoding RNAs that post-transcriptionally regulate express...

Full description

Bibliographic Details
Main Authors: Kotani, Ai (Author), Ha, Daon (Contributor), Schotte, Diana (Author), den Boer, Monique L. (Author), Armstrong, Scott A. (Author), Lodish, Harvey F (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Lodish, Harvey F. (Contributor)
Format: Article
Language:English
Published: Landes Bioscience, 2012-10-22T20:44:30Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items