Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

A molecule that treats multiple age-related diseases would have a major impact on global health and economics. The SIRT1 deacetylase has drawn attention in this regard as a target for drug design. Yet controversy exists around the mechanism of sirtuin-activating compounds (STACs). We found that spec...

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Main Authors: Hubbard, B. P. (Author), Gomes, A. P. (Author), Dai, H. (Author), Li, J. (Author), Case, A. W. (Author), Considine, T. (Author), Riera, T. V. (Author), Lee, J. E. (Author), Yen, E. Sook (Author), Lamming, D. W. (Author), Schuman, E. R. (Author), Stevens, L. A. (Author), Ling, A. J. Y. (Author), Armour, S. M. (Author), Michan, S. (Author), Zhao, H. (Author), Jiang, Y. (Author), Sweitzer, S. M. (Author), Blum, C. A. (Author), Disch, J. S. (Author), Ng, Pui Yee (Author), Howitz, K. T. (Author), Rolo, A. P. (Author), Hamuro, Y. (Author), Moss, Joel (Author), Perni, R. B. (Author), Ellis, J. L. (Author), Vlasuk, G. P. (Author), Sinclair, D. A. (Author), Pentelute, Bradley L. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2013-11-22T18:32:32Z.
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