De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)-scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-...

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Bibliographic Details
Main Authors: Del Vecchio, Catherine A. (Author), Feng, Yuxiong (Author), Sokol, Ethan Samuel (Contributor), Tillman, Erik J. (Contributor), Sanduja, Sandhya (Author), Reinhardt, Ferenc (Author), Gupta, Piyush (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-10-15T19:44:20Z.
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